From Wikipedia, we learn how Lisa got her position to cause trouble: Murkowski was appointed to the U.S. Senate by her father, Frank Murkowski, who resigned his seat in December 2002 to become the Governor of Alaska. She completed her father's unexpired term, which ended in January 2005. She ran for and won a full term in 2004.
She ran for a second term in 2010. She lost the Republican Party nomination to Tea Party candidate Joe Miller. She then ran as a write-in candidate and defeated both Miller and Democrat Scott McAdams in the general election.
I predict, having displayed her loyalty to the establishment with this vote, that she will see a strong primary challenge. That write in game worked once, but will it work again? She may find out if she keeps this up.